C. difficile

By Targets:	Antibiotic (6) Bacterial (12) DNA/RNA Synthesis (2) Isotope-Labeled Compounds (2)
By Research Areas:	Infection (14) Inflammation/Immunology (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P9929

Bezlotoxumab	Bacterial	Infection Inflammation/Immunology
Bezlotoxumab is a human monoclonal antibody directed against C. difficile toxin B. Bezlotoxumab binds to C. difficile toxin B preventing intestinal epithelial damage and colitis .

HY-B0975

Penicillin V Potassium Phenoxymethylpenicillin potassium salt	Bacterial Antibiotic	Infection
Penicillin V Potassium (Phenoxymethylpenicillin potassium salt) is an orally active antibiotic. Penicillin V Potassium inhibits the growth of Streptococci, C. difficile and S. aureus. Penicillin V Potassium can be used for the research of otitis, sinusitis, pharyngitis and tonsillitis .

HY-156283

Antibacterial agent 159	Antibiotic	Infection
Antibacterial agent 159 (Compound 6d) is an antibiotic. Antibacterial agent 159 can effective against impetigo and C. difficile infection (CDI). Antibacterial agent 159 has no observed recurrence for C. difficile and exertes a minimal impact on the beneficial gut microbiome .

HY-163142

Antibacterial agent 172	Bacterial	Infection
Antibacterial agent 172 (Compound 6a) is a <,i>Clostridioides difficile (Cd) SpoVD inhibitor (IC₅₀=89 nM) that effectively inhibits sporulation of Clostridioides difficile. Antibacterial agent 172 can be used in the study of bacterial infections .

HY-18324

CRS3123 REP-3123	Antibiotic	Inflammation/Immunology
CRS3123 is a potent and orally active narrow-spectrum antibiotic. CRS3123 inhibits bacterial methionyl-tRNA synthetase. CRS3123 has potent activity against Clostridium difficile (C. difficile) and aerobic Gram-positive bacteria but little activity against Gram-negative bacteria, including anaerobes. CRS3123 has the potential for the research of C. difficile infections .

HY-128357

Ibezapolstat ACX-362E; GLS-362E	Bacterial DNA/RNA Synthesis	Infection
Ibezapolstat (ACX-362E) is a first-in-class, orally active DNA polymerase IIIC (pol IIIC) inhibitor, with a K_i of 0.325 μM for the DNA pol IIIC from C. difficile. Ibezapolstat is developed for the research of C. difficile infection(CDI) .

HY-156282

Antibacterial agent 158

Bacterial Infection

Antibacterial agent 158 (compound 6c), a Micrococcin analogue, and is effective against impetigo and C. difficile infection (CDI) .
HY-16753

Ridinilazole

SMT19969
Bacterial Infection

Ridinilazole is a novel antibacterial with MICs range of 0.06-0.25 µg/mL (MIC₉₀=8 µg/mL) against C. difficile.

Antibacterial agent 158	Bacterial	Infection
Antibacterial agent 158 (compound 6c), a Micrococcin analogue, and is effective against impetigo and C. difficile* infection* (CDI) .

Ridinilazole SMT19969	Bacterial	Infection
Ridinilazole is a novel antibacterial with MICs range of 0.06-0.25 µg/mL (MIC₉₀=8 µg/mL) against C. difficile.

HY-B0975S

Penicillin V-13C6 potassium Phenoxymethylpenicillin-¹³C₆ potassium salt	Isotope-Labeled Compounds Bacterial Antibiotic	Infection
Penicillin V- ¹³C₆ (potassium) is the ¹³C₆ labeled Penicillin V (potassium). Penicillin V Potassium (Phenoxymethylpenicillin potassium salt) is an orally active antibiotic. Penicillin V Potassium inhibits the growth of Streptococci, C. difficile and S. aureus. Penicillin V Potassium can be used for the research of otitis, sinusitis, pharyngitis and tonsillitis.

HY-163042

HSGN-218	Bacterial	Infection
HSGN-218 is an antibacterial agent with low Caco-2 permeability. HSGN-218 efficiently inhibits the growth of different C. difficile species with MIC values ranging from 0.007 μM to 0.07 μM.

HY-148041

ATPase-IN-2	Others	Others
ATPase-IN-2 is an ATPase inhibitor with an IC₅₀ value of 0.9 μM. ATPase-IN-2 inhibits C. difficile toxin B (TcdB) glycohydrolase activity with an AC₅₀ value of 30.91 μM. ATPase-IN-2 can be used for the research of ATP-related .

HY-149610

Antibacterial agent 156	Bacterial	Infection
Antibacterial agent 156 (Compound 57) is a selective and potent bactericidal against C. difficile and targets cell-wall synthesis. Antibacterial agent 156 exhibits bactericidal activity with the minimal inhibitory concentration of 0.5 μg/mL and 1 μg/mL against MIMIC50 (101 strains) and MIC90 (101 strains) .

HY-B0975AS

Penicillin V-d5	Isotope-Labeled Compounds Bacterial Antibiotic	Infection
Penicillin V-d₅ (Phenoxymethylpenicillin-d5) is the deuterium labeled Penicillin V. Penicillin V (Phenoxymethylpenicillin) is an orally active antibiotic. Penicillin V inhibits the growth of Streptococci, C. difficile and S. aureus. Penicillin V can be used for the research of otitis, sinusitis, pharyngitis and tonsillitis[1][2][3][4].

HY-B0975S1

Penicillin V Potassium-d5 Phenoxymethylpenicillin-d₅ potassium salt	Bacterial Antibiotic	Infection
Penicillin V (Potassium)-d₅ is the deuterium labeled Penicillin V Potassium[1]. Penicillin V Potassium (Phenoxymethylpenicillin potassium salt) is an orally active antibiotic. Penicillin V Potassium inhibits the growth of Streptococci, C. difficile and S. aureus. Penicillin V Potassium can be used for the research of otitis, sinusitis, pharyngitis and tonsillitis[2][3][4][5].

HY-105099

Rifalazil KRM-1648; ABI-1648	DNA/RNA Synthesis Bacterial	Infection Inflammation/Immunology
Rifalazil (KRM-1648; ABI-1648), a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymerase . Rifalazil (KRM-1648; ABI-1648) is an antibiotic, exhibits high potency against mycobacteria, gram-positive bacteria, Helicobacter pylori, C. pneumoniae and C. trachomatis with MIC values from 0.00025 to 0.0025 μg/ml . Rifalazil (KRM-1648; ABI-1648) has the potential for the treatment of Chlamydia infection, Clostridium difficile associated diarrhea (CDAD), and tuberculosis (TB) .

Cat. No.	Product Name	Target	Research Area

HY-P99277

Actoxumab Anti-C. difficile Toxin A Recombinant Antibody	Inhibitory Antibodies	Infection
Actoxumab (Anti-C. difficile Toxin A Recombinant Antibody) is a antitoxin antibody against C. difficile toxin A by neutralizing TcdA. Actoxumab prevents both the damage to the gut wall and the inflammatory response, which are associated with C. difficile. Actoxumab has synergy effect with Bezlotoxumab (HY-P9929) targeting TcdB .

HY-P9929

Bezlotoxumab	Bacterial	Infection Inflammation/Immunology
Bezlotoxumab is a human monoclonal antibody directed against C. difficile toxin B. Bezlotoxumab binds to C. difficile toxin B preventing intestinal epithelial damage and colitis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0975

Penicillin V Potassium Phenoxymethylpenicillin potassium salt	Infection Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Beta-lactam Antibiotics	Bacterial Antibiotic
Penicillin V Potassium (Phenoxymethylpenicillin potassium salt) is an orally active antibiotic. Penicillin V Potassium inhibits the growth of Streptococci, C. difficile and S. aureus. Penicillin V Potassium can be used for the research of otitis, sinusitis, pharyngitis and tonsillitis .

Cat. No.	Compare	Product Name	Species	Source

HY-P79219

	*Toxin B/TcdB Protein, C. difficile* (His)** Toxin B; Glucosyltransferase TcdB; toxB	Others	E. coli
	Toxin B/TcdB protein is the precursor of the cytotoxin TcdB, which can strategically destroy the colon epithelium and cause host inflammatory response and diarrhea in Clostridium difficile infection. Compared with TcdA, TcdB has higher virulence and is essential for eliciting host responses. Toxin B/TcdB Protein, C. difficile (His) is the recombinant Toxin B/TcdB protein, expressed by E. coli , with C-6*His labeled tag. The total length of Toxin B/TcdB Protein, C. difficile (His) is 543 a.a., with molecular weight of approximately 65 kDa.


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Cat. No.	Product Name	Chemical Structure

HY-B0975AS

Penicillin V-d5
Penicillin V-d₅ (Phenoxymethylpenicillin-d5) is the deuterium labeled Penicillin V. Penicillin V (Phenoxymethylpenicillin) is an orally active antibiotic. Penicillin V inhibits the growth of Streptococci, C. difficile and S. aureus. Penicillin V can be used for the research of otitis, sinusitis, pharyngitis and tonsillitis[1][2][3][4].

HY-B0975S

Penicillin V-13C6 potassium
Penicillin V- ¹³C₆ (potassium) is the ¹³C₆ labeled Penicillin V (potassium). Penicillin V Potassium (Phenoxymethylpenicillin potassium salt) is an orally active antibiotic. Penicillin V Potassium inhibits the growth of Streptococci, C. difficile and S. aureus. Penicillin V Potassium can be used for the research of otitis, sinusitis, pharyngitis and tonsillitis.

HY-B0975S1

Penicillin V Potassium-d5
Penicillin V (Potassium)-d₅ is the deuterium labeled Penicillin V Potassium[1]. Penicillin V Potassium (Phenoxymethylpenicillin potassium salt) is an orally active antibiotic. Penicillin V Potassium inhibits the growth of Streptococci, C. difficile and S. aureus. Penicillin V Potassium can be used for the research of otitis, sinusitis, pharyngitis and tonsillitis[2][3][4][5].

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C. difficile

Inhibitors & Agonists

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Natural
Products